Niacinamide (Iyo panacea munyika yekuchengetedza ganda)
Niacinamide, inozivikanwawo sevhitamini B3 (VB3), ndiyo biologically active form ye niacin uye inowanikwa zvakanyanya mumhando dzemhuka nemiti.Iyo zvakare yakakosha precursor ye cofactors NADH (nicotinamide adenine dinucleotide) uye NADPH (nicotinamide adenine dinucleotide phosphate).Pamwe chete neNADH yakaderedzwa uye NADPH, vanoita semacoenzymes mune zvinopfuura makumi mana biochemical reactions uye zvakare vanoita se antioxidants.
Mukiriniki, inonyanya kushandiswa kudzivirira uye kurapa pellagra, stomatitis, glossitis nezvimwe zvirwere zvine hukama.
basa rinokosha
1.Ganda rinopenya nekuchena
Nicotinamide inogona pasi-kugadzirisa kutakurwa kwe melanosomes kubva ku melanocytes kuenda ku keratinocytes pasina inhibiting tyrosinase chiitiko kana kuwanda kwesero, nekudaro kukanganisa ganda pigmentation.Inogonawo kukanganisa kudyidzana pakati keratinocytes uye melanocytes.Masero ekuisa chiratidzo pakati pemasero anoderedza kugadzirwa kwe melanin.Kune rimwe divi, nicotinamide inogona kuita pane yakatogadzirwa melanin uye kuderedza kutamiswa kwayo kumaseru epamusoro.
Imwe pfungwa yekuona ndeyekuti nicotinamide inewo basa reanti-glycation, iyo inogona kuderedza iyo yero ruvara rweprotein mushure me glycation, iyo ichave inobatsira pakuvandudza ruvara rweganda remuriwo-ruvara zviso uye kunyange "yero-vakadzikadzi".
Wedzera kunzwisisa
Kana niacinamide ichishandiswa sechinhu chinochenesa, pachikamu che2% kusvika 5%, yakaratidza kuti inoshanda mukurapa chloasma uye hyperpigmentation inokonzerwa nemirairo yeultraviolet.
2.Anti-kuchembera, kuvandudza mitsetse yakanaka (anti-free radicals)
Niacinamide inogona kumutsa collagen synthesis (inowedzera kukurumidza uye huwandu hwecollagen synthesis), kuwedzera elasticity yeganda, uye kuderedza kutaridzika kwemitsara yakanaka nemakwinya.Iyo ine zvakare antioxidant zvimiro zvinomisa mahara radicals uye inonoke kuchembera kweganda.
Wedzera kunzwisisa
Zvidzidzo zvakaratidza kuti kushandisa nicotinamide (5% yemukati) kunogona kuderedza kuunyana, erythema, kutsvuka uye makwapa paganda rekuchembera rechiso.
3.Gadzirisa gandachipingamupinyi basa
Kugadziriswa kweNiacinamide kweganda barriers basa rinonyanya kuratidzwa mune maviri maficha:
① Kurudzira kuumbwa kweceramide muganda;
②Kurumidza kusiyanisa masero ekeratin;
Topical application yenicotinamide inogona kuwedzera mazinga emahara emafuta acids uye ceramides paganda, inomutsa microcirculation mudermis, uye kudzivirira kurasikirwa kwemwando weganda.
Inowedzerawo protein synthesis (yakadai sekeratin), inowedzera intracellular NADPH (nicotinamide adenine dinucleotide phosphate) mazinga, uye inokurumidza kusiyanisa keratinocyte.
Wedzera kunzwisisa
Iko kugona kuvandudza basa reganda rinodzivirira rataurwa pamusoro rinoreva kuti niacinamide ine hunyoro hwekugona.Zvidzidzo zvidiki zvinoratidza kuti topical 2% niacinamide inoshanda kupfuura petroleum jelly (petroleum jelly) mukudzikisa kurasikirwa kwemvura yeganda uye kuwedzera hydration.
Yakanakisa kusanganiswa kwezvigadzirwa
1. Musanganiswa wekuchena nekubvisa freckle: niacinamide +retinol A
2. Musanganiswa wakadzama wekunyorova:hyaluronic acid+ squalane
Nguva yekutumira: Kubvumbi-29-2024
